Helicos® Genetic Analysis System Performance Specifications Instrument Performance / Configuration Flow Cells 2 flow cells processed simultaneously 50 independent channels are available in 2 flow cells Sample Throughput 1 – 100,000+ samples per run1 Sequencer Throughput > 1 Gigabases per hour2 SEQUENCING PERFORMANCE AS OF December 1, 2008   Routine Usage Specifications3 Strand Output 12 to 16M usable strands per channel4 600 to 800M usable strands per run Total Output 420 to 560 Megabases per channel 21 to 28 Gigabases per run Throughput 105 to 140 Megabases per hour Read Length 25 to 55 bases in length 30 to 35 average length Accuracy >99.995% consensus accuracy at >20X coverage Raw Error Rate <5% (~0.5% for substitutions) Consistent from 20-80% GC content of target DNA Independent of Read Length and Template Size Template Size 25 to 5,000 bases 1 >50 samples per run possible with molecular barcoding and sample multiplexing 2 The imaging system is designed for 1 Gigabase/hour throughput performance. Actual sequencing performance is determined by chemistry efficiency and loading density 3 Routine usage specifications based on genomic DNA samples loaded at recommended concentrations and 30 Quad run (8 days) 4 Usable strands are defined at >25 base pairs in length and at the defined raw error rate

To view the complete specifications document click here (pdf).