To achieve a higher level of sequence accuracy unmatched by any other technology. Helicos has developed a method for sequencing each single molecule template multiple times. This novel sequencing approach enables researchers to generate data sets with a high degree of accuracy.
Multi-pass sequencing assures a statistical base calling accuracy consistent with industry standards, and assures maximum confidence in deep sequencing applications — where even a single base can make a significant difference in your research. It opens the door to applications that require exceptional sequence accuracy to find rare events. For example, heterogeneous cancer samples can be analyzed to find functional single base mutations, and rare disease mutations can be confidently identified in association studies.
See some of the applications that can benefit from multi-pass sequencing: