-- Joint Publication on Differential Gene Expression from Small Number of Tumor Cells --

CAMBRIDGE, Mass., Jul 20, 2010 (BUSINESS WIRE) -- Helicos BioSciences Corporation (NASDAQ: HLCS) today announced a publication entitled "Amplification-free digital gene expression profiling from minute cell quantities" appearing on line in Nature Methods co-authored by Dr. Daniel A. Haber and colleagues from Massachusetts General Hospital. The paper demonstrates the quantitative capabilities of Helicos' single-molecule sequencing technology and its potential to reveal important genomic differences when minimal numbers of cells are available for analysis.

"This paper demonstrates significant potential clinical advantages of the single molecule-sequencing platform. The method can effectively utilize a very small number of cells for accurate molecular characterization, while being less prone to errors and representational biases seen with other sequencing techniques," said Daniel A. Haber, M.D., Ph.D., Director of the Massachusetts General Hospital Cancer Center.