Sequencing at significantly greater speed and much lower cost than other methods, the Helicos™ Genetic Analysis Platform opens up exciting new territory in basic and translational research. With the ability to directly examine DNA, RNA sequence and DNA structure at the single molecule level, True Single Molecule Sequencing (tSMS)™ technology has tremendous potential as a universal platform for unraveling the complex biology of the genome. In addition, by enabling cost-effective comparison of genes and genomes from thousands of individuals, tSMS technology will unlock the era of genomic medicine. It is our belief that Helicos will enable researchers world-wide to transform the way disease is studied, diagnosed and treated. Helicos-enabled discoveries will lead to more accurate molecular diagnostics for cancer and other diseases, improved drug therapies and personalized medical treatments.

One platform, multiple applications The Helicos Genetic Analysis Platform is extremely versatile and can be applied to a wide range of pharmacogenomics and biomedical applications, such as:

• Gene expression high throughput screening (GE-HTS)
• Whole genome resequencing
• Candidate region sequencing
• Digital gene expression profiling
• miRNA profiling and discovery
• Methylation
• Copy number variations
• Allelic imbalance
• Genomic rearrangements
• Paraffin embedded tissue DNA