Thanks to our breakthrough true direct DNA measurement technology, the HeliScope™ Single Molecule Sequencer has been designed to enable affordable and rapid resequencing of whole human genomes. This provides a direct and comprehensive catalog of genomic mutations. Eventually, as the number of sequenced whole genomes grows, the genes and mutations responsible for disease susceptibility, progression, outcome and response to therapy will be elucidated, leading to dramatic improvements in patient diagnosis and care.

The ability to analyze hundreds to thousands of whole human genomes in a cost-effective manner will have fundamental implications for disease research:

• It will significantly enhance the understanding of normal genome function and regulation.
• It will allow disease association studies at a scale never before possible, comparing genomes from thousands of patients.
• It will permit the characterization of all genetic abnormalities in various cancers.